Securin correct separation
نویسندگان
چکیده
منابع مشابه
Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
Sister chromatid attachment during meiosis II (MII) is maintained by securin-mediated inhibition of separase. In maternal ageing, oocytes show increased inter-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant separase activity. Here, we find that MII oocytes from aged mice have less securin than oocytes from young mice and that this reduction is m...
متن کاملRegulation of Human Separase by Securin Binding and Autocleavage
BACKGROUND Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion. Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates. In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, w...
متن کاملSecurin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.
We have studied the ubiquitination and degradation patterns of the human securin/PTTG protein. We show that, in contrast to budding yeast pds1, securin degradation is catalyzed by both fzy (fizzy/cdc20) and fzr (fizzy-related/cdh1/hct1). Both fzy and fzr also induce the APC/C to ubiquitinate securin in vitro. Securin degradation is mediated by an RXXL destruction box and a KEN box, and is inhib...
متن کاملUbiquitin receptor found
have identified an endosomal receptor complex that pushes proteins into the lumen of endosomes destined for the vacuole. This internalization step represents another possible site of regulation for controlling receptor activity. Receptors and other plasma membrane proteins bound for destruction are tagged with one or more ubiquitin (Ub) molecules before they are internalized in vesicles that fu...
متن کاملSecurin and separase modulate membrane traffic by affecting endosomal acidification.
Securin and separase play a key role in sister chromatid separation during anaphase. However, a growing body of evidence suggests that in addition to regulating chromosome segregation, securin and separase display functions implicated in membrane traffic in Caenorhabditis elegans and Drosophila. Here we show that in mammalian cells both securin and separase associate with membranes and that dep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1581rr3